Musheng Zeng, Ph.D.
Professor of Oncology
Principle Investigator
State Key Laboratory of Oncology in Southern China
Cancer Institute, Sun Yat-sen University
651 Dongfeng Rd. East
Guangzhou, China 510060
Phone: (8620) 87343191
Fax: (8620) 87343392
Email: zengmsh@mail.sysu.edu.cn
mszeng@hotmail.com


Dr. Zeng received his PhD degrees from Sun Yat-sen University of Medical Sciences in 1998, where he was introduced in the field of molecular mechanism of nasopharyngeal carcinogenesis. Musheng then worked as a postdoctoral fellow at the Department of Radiation Oncology in Tufts University-New England Medical Center in Boston under the instruction of Professor Vimla Band, where he was concentrated on the research of HPV E6 targeted proteins. In 2003, Dr. Zeng returned to China and continued his research career in nasopharyngeal carcinomas (NPC).

Dr. Zeng’s research on EBV variation led to the analysis of the whole genomic sequence from a Cantonese NPC derived EBV. The studies on cellular oncogenes led to identification of the potential role of the polycomb protein Bmi-1 in NPC as well as establishment of Bmi-1 immortalized nasopharyngeal epithelial cell lines. His current research focuses on the molecular events required for early transformation of nasopharyngeal epithelial cells as well as early diagnosis of NPC.

Current Major Grants:
1. PI Study of new diagnostic methods for Nasopharyngeal Carcinoma. “863” project from Ministry of Science and Technology of China
2. Basic Study of Early Diagnosis for Nasopharyngeal Carcinomas, Key grant from National Natural Science Foundation of China, 2007-2010, 1,400,000 RMB
3. PI. New Centurial Outstanding Youth Grant from Department of Education of China, 2006-2010, 500,000 RMB
4. PI. Comparison of transforming ability between prototype EBV and NPC derived EBV in human nasopharyngeal epithelial cells, National Natural Science Foundation of China, 2006-2008, 280,000 RMB
5. PI. Transforming ability of NPC derived EBV genes in human primary nasopharyngeal epithelial cells, National Natural Science Foundation of China, 2005-2007, 200,000 RMB

Representative Publications (* corresponding author):
1. Liao WT, Song LB, Zhang HZ, Zhang X, Zhang L, Liu WL, Feng Y, Guo BH, Mai HQ, Cao SM, Li MZ, Qin HD, Zeng YX, Zeng MS*. CENP-H is a Novel Prognostic Marker for Nasopharyngeal Carcinoma Progression and Overall Patient Survival. Clin Cancer Res（IF 5.6）, 2007，13(2):508-14.
2. Song LB, Zeng MS*, Liao WT, Zhang L, Mo HY, Liu WL, Shao JY, Wu QL, Li MZ, Xia YF, Fu LW, Huang WL, Dimri G, Band V and Zeng YX. Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells. Cancer Research（IF 7.7），2006；66 (12)：6225
3. Song LB, Liao WT, Mai HQ, Zhang HZ, Zhang L, Li MZ, Hou JH, Fu LW, Huang WL, Zeng YX, Zeng MS*. The Clinical Significance of Twist Expression in Nasopharyngeal Carcinoma. Cancer Letters（IF 2.9）2006；242（2）：257
4. Jiang RC, Qin HD, Zeng MS (each contribution of first three authors), et al. A functional variant in the transcriptional regulatory region of gene LOC344967 co-segregates with disease phenotype in familial nasopharyngeal carcinoma. Cancer Res（IF 7.8）, 2006; 66(2)：693-700
5. Zeng M, Zhang Y, Bhat I, Wazer D and Band V. The human kallikrein 10 promoter contains a functional retinoid acid response element. Biol Chem.（IF 3.2）2006, 387（6）：741
6. Zeng MS, Li DJ, Liu QL, et al. Genomic sequence analysis of an Epstein-Barr virus strain GD1 from a nasopharyngeal carcinoma patient. J Virol （IF 5.3） 2005, 79 (24):15323-15330
7. Zeng M, Kumar A, Meng G, Gao Q, Dimri G, Wazer D, Band H and Band V. Human papilloma virus 16 E6 oncoprotein inhibits RXR-mediated transactivation by targeting human ADA3 coactivator. J Biol Chem（IF 6.3） 2002; 277(47): 45611-45618
8. Guo WJ, Zeng MS, Yadav A, Song LB, Guo BH, Band V, Dimri GP. Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells. Cancer Res（IF 7.7）. 2007;67(11):5083-9
9. Zhao Y, Katzman RB, Delmolino LM, Bhat I, Zhang Y, Gurumurthy CB, Germaniuk-Kurowska A, Reddi HV, Solomon A, Zeng MS, Kung A, Ma H, Gao Q, Dimri G, Stanculescu A, Miele L, Wu L, Griffin JD, Wazer DE, Band H, Band V. The notch regulator MAML1 interacts with p53 and functions as a coactivator. J Biol Chem. 2007; 282(16):11969-81
10. Xue G, Liu RY, Li Y, Cheng Y, Liang ZH, Wu JX, Zeng MS, Tian FZ, Huang W. Dendritic cells modified with 6Ckine/IFNgamma fusion gene induce specific cytotoxic T lymphocytes in vitro. Cancer Immunol Immunother. 2007;56(11):1831-43
11. Mai SJ, Ooka T, Li DJ, Zeng MS, Jiang RC, Yu XJ, Zhang RH, Chen SP, Zeng YX. Functional advantage of NPC-related V-val subtype of Epstein-Barr virus nuclear antigen 1 compared with prototype in epithelial cell line. Oncol Rep. 2007; 17(1):141-6.
12. Dai CL, Xiong HY, Tang LF, Zhang X, Liang YJ, Zeng MS, Chen LM, Wang XH, Fu LW. Tetrandrine achieved plasma concentrations capable of reversing MDR in vitro and had no apparent effect on doxorubicin pharmacokinetics in mice. Cancer Chemother Pharmacol. 2007 Feb 2 [Epub ahead of print]
13. Jiang JH, Wang N, Li A, Liao WT, Pan ZG, Mai SJ, Li DJ, Zeng MS, Wen JM, Zeng YX. Hypoxia can contribute to the induction of the Epstein-Barr virus (EBV) lytic cycle. J Clin Virol. 2006; 37(2):98-103.
14. Wang XH, Jia DZ, Liang YJ, Yan SL, Ding Y, Chen LM, Shi Z, Zeng MS, Liu GF, Fu LW. Lgf-YL-9 induces apoptosis in human epidermoid carcinoma KB cells and multidrug resistant KBv200 cells via reactive oxygen species-independent mitochondrial pathway. Cancer Lett. 2006 Oct 19; [Epub ahead of print]
15. Wang N, Wu QL, Fang Y, Mai HQ, Zeng MS, Shen GP, Hou JH, Zeng YX. Expression of chemokine receptor CXCR4 in nasopharyngeal carcinoma: pattern of expression and correlation with clinical outcome. J Transl Med. 2005 Jun 26;3:26.
16. Meng G, Zhao Y, Nag A, Zeng M, et al. Human ADA3 binds to estrogen receptor (ER) and functions as a coactivator for ER-mediated transactivation. J Biol Chem, 2004, 279(52):54230-40
17. Asson Batres MA, Zeng MS, McKanna J, and Savchenko V. Vitamin A Deficiency Leads to Increased Cell Proliferation in Olfactory Epithelium of Mature Rats. J Nurobio,l 2003, 54(4): 539.
18. Kumar A, Zhao Y, Meng G, Zeng M, et al. Human papillomavirus oncoprotein E6 inactivates the transcriptional coactivator human ADA3. Mol Cell Biol, 2002, 22(16): 5801-12
19. Guoxiang, Min HQ, Zeng MS, et al. Nm23-H1 expression in nasopharyngeal carcinoma: Correlation with clinical outcome. Int J Cancer, 1998, 79, 596