PART I:  General Information 

Name:  Jian-chuan Xia Ph.D and MD, Full Professor

Address; The biotherapy center of cancer center in Sun-Yat Sen university 

E-Mail: Xiajc51@hotmail.com , Xiajc51@ gzsums.edu.cn.

Place of Birth:  Jianxi Province, People's Republic of China 

Education: 

1995.9-1998.6    Ph.D.   (Medicine) Harbin Medical University 

1998.8-2000.7   Postdoctoral  Fellow  Cancer Genetics Cancer Institute, Sun Yat-Sen University of   Medical Sciences 

2000.8-2003.6    Postdoctoral  Fellow:  Dana-Farber Cancer Institute, Harvard medical school 

Professional Societies:

   Editor  Chinese Journal of Cancer

   National Institute for the Control of Pharmaceutical & Biological Products

   Chinese Medical Association Member

   Genetics Society of China Member 

Awards and Honors:

1996 First Prize for Excellence in Scientific,   Publication of the Heilongjiang Science Association

1997 First Prize for Achievement in  Scientific Research of the Educational Committee of Heilongjiang

1998 Second Prize for Achieveent in  Scientific Research of the Scientific,  Technology Committee of Heilongjiang  

Part II:  Laboratory and Cinical Investigator Ladders 

A. Report of Research

1.   Major research interests
      Molecular biology and molecular cytogenetics of cancer
     Medical genetics, chromosomal markers, cytogenetics, biology, and biological Chemistry
    Tumor immunotherapy 
2.   Narrative description of research 

    In May of 1997 I was conferred a Ph.D. from Harbin Medical University in China.  During my studies for the Ph.D., my research was focused upon the study of related genes in human gastric cancer.  This project was a collaboration with the National Institutes of Health in the United States of America.  By using molecular biological techniques, as well as molecular cytogenetics techniques such as FISH, CGH, and PCR, I found out the close correlation between the del (7q) and the pathogenesis of gastric cancers and suggested the frequent 7q31-q35 might contain a tumor suppressor gene for the progression of gastric cancer.  My research led to two papers published in the Chinese Journal of Medical Science, a high quality journal in China; and Cytogenetics in the United States, respectively.  Based on my outstanding research, I was invited to perform the study of the identification of nasopharyngeal carcinoma (NPC) susceptibility genes in the Chinese National Human Genome Center at Shanghai, as a postdoctoral fellow of the Sun Yat-Sen University of Medical Sciences (SUMS).  I mapped the nasopharyngeal carcinoma susceptibility genes on human chromosomes 4p12-15 by micro-satellite markers linkage analysis of NPC family members.  My research led to a publication in  Nature Genetics, "Genome-wide scan for familial nasopharyngeal carcinoma and evidence for linkage to chromosome 4," In October of 2000, I was invited to Dana-Farber Cancer Institute of Harvard Medical School to conduct tumor vaccine studies as a postdoctoral fellow. My research led to two publication in the Journal of immunology and Immunology respectively. I obtained many National Natural Scientific Foundation of China and Natural Scientific Foundation of Guangdong province .  So far I have published more than 20 papers.  

Part III:  Original Articles 

1)       Xia JC, et al Development of Antigen-Specific CD8+ Cytotoxic T Lymphocytes in MHC Class I-Deficient Mice through CD4 to CD8 Conversion J Immunol 2004 March received.

2)       Xia JC, et al. Prevention of spontaneous breast carcinoma by prophylactic vaccination with dendritic/tumor fusion cells. J Immunol 2003 Feb 15;170(4):1980-1986.

3)       Chen D,Xia JC, et al Immunotherapy of spontaneous mammary carcinma with fusions of dendritic cell and mucin 1-positive carcinoma calls. Immunology 2003;109:300-307

4)       Guan XY, Fu SB, Xia JC, et al. Trent JM. Recurrent chromosome changes in 62 primary gastric carcinomas detected by comparative genomic hybridization. Cancer Genet Cytogenet 2000;123:27-34.

5)       Xia JC, et al. Direct chromosome analysis of ten primary gastric cancer.  Cancer Genet Cytogenet.1998;102(1);88-90.

6)       Xia JC, et al. Direct chromosome analysis and FISH detection of 28 primary gastric cancers. Chinese J Cancer Res 2000;12:168-172.

7)      Xia JC, Xiao S, Zhang JH, Li P. Detecting complicated chromosome rearrangements of cancer with the improved method of fluorescence in situ hybridization (FISH) performed on de-stained G-banding chromosomes. Chinese J Med Genet 2000;17:68-73.

8)       Xia JC, et al. Direct chromosome aberrations in twelve primary gastric cancer by direct chromosome analysis and FISH.  Chinese Medical Science Jounal,1999, 14(1):7.

9)       Feng BJ, Huang W, Shugart YY, Lee MK, Zhang F, Xia JC, Wang HY, Huang TB, Jian SW, Huang P, Feng QS, Chen Z, Zeng YX. Genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4. Nat Genet 2002 Aug;31(4):395-9

10)   Xia JC, Zhang JH, Lu S  Application of gene amplification detected by  combined chromosomal microdissection and comparative genomic hybridization.  J Foreign Med 1998;21: 4-7.

11)    Xia JC, Zhang JH, Lu S. The molecular mechanism study of gastric   pathogenesis.  J Foreign Med1998;21:139-142.

12)     Xia JC, Lu S, Zhang JH, Li P, Liu QZ.  Direct chromosome analysis of fifty  primary digestive tract cancers. Chinese J Med Genet 1998;12:179-182.

13)     Xia JC, Lu S, Zhang JH, Ning XM, Liu QZ, Li P.  Detection of chromosome  aberrations in twelve primary gastric cancers by direct chromosome analysis and   FISH.  Chinese Med Sci J 1999;14:7-12.Xia JC, Lu S, Geng JS, Liu QZ, Li P.  The direct chromosome analysis and        FISH detection of 28 primary gastric cancers.  Chinese J Cancer 1999;21:345-349.

14)    Xia JC, Xiao S, Zhang JH, Li P.  Detecting complicated chromosome  rearrangements of cancer with the improved method of fluorescence in situ   hybridization (FISH) performed on de-stained G-banding chromosomes.  Chinese J  Med Genet 2000;17:68-73.

15)   Lu S, Xia JC, Zhang JH.  DNA fiber fluorescence in situ hybridiization.  J Foreign Med Genet 1997;20:284-287.

16)    Zhang JH, Zhong ZH, Xia JC.  Diagnosis of herpes virus cerebritis by the  application of PCR, virus isolation and DNA hybridization.  J Gannan Medical  College 1997;23:102.

17)    Xia JC, Lu S, Zhang JH.  Cytogenetic study of thirty primary digestive tract   cancers.  J Harbin Med Univ 1997;23:1-4.

18)     Xia JC, Xiao S, Geng JS, Liu QZ, Li P.  Cytogenetic abnormalities in twelve  primary gastric cancers.  J Harbin Med Univ 1997;31:201-206.

19)   Xia JC, Zeng YX, Li P.  Direct chromosome analysis and FISH detection of 28   primary gastric cancers.  Chinese J Cancer Res 2000;12:168-172.

20)   Lu S, Xia JC, Zhang JH.  Comparative genomic hybridization and its application  in molecular cytogenetic studies of tumor.  J Foreign Med Genet 1997;20:172-175.

21)   Shao JY, Huang XM, Yu XJ, Huang LX, Wu QL, Xia JC, et al. Loss of heterozygosity and its correlation with clinical outcome and Epstein-Barr virus infection in nasopharyngeal carcinoma. Anticancer Res 2001;21(4B):3021-3029.

22)   Zhang XS, Song KH, Mai HQ, Jia WH, Feng BJ, Xia JC, Zhang RH, Huang LX, Yu XJ, Feng QS, Huang P, Chen JJ, Zeng YX. The 30-bp deletion variant: a polymorphism of latent membrane protein 1 prevalent in endemic and non-endemic areas of nasopharyngeal carcinomas in China. Cancer Lett  2002 Feb 8;176(1):65-73

23)   Lu YJ, Xia JC.  Genetics study of the progression of breast cancers.  J  Foreign Med 1992;3:178-183.

24)   Xia JC, Xiao S, Zhang JH.  Cytogenetics studies in advance of esophageal   cancer.  J. Foreign Med 1993;4(Genetics Section):248-251.

25)    Xia JC, Zhang JH.  Cytogenetic studies of the progression of gastric cancers.  J Foreign Med 1994;1(Genetics Section):27-31.

26)     Xia JC, Xiao S, Li P, Xhang JH.  Cytogenetic study of sixteen primary gastric cancers.  Chinese J Med Genet 1994;11:1-4.