INTRODUCTION
HISTORY
MAIN LEADERS
DEPARTMENTS
SPECIALISTS
RESEARCH
EDUCATION
PREVENTION
HONOUR
INTERNATIONAL
 You are here: Home >specialists> Zhongping Chen
   Zhongping Chen

       Zhongping Chen, M.D., Ph.D. Professor and Chairman
Department of Neurosurgery/Neuro-Oncology
Cancer Center, SunYat-Sen University
President of Guangzhou Neuro-Oncology Society

ADDRESS: 651 DongFeng Road East
                     Guangzhou, 510060 P. R. China
                     Telephone & Fax: 020-87343310( in China)
                                                                  Fax: (708)570-5940 ( in North America)
                                                                  E-mail: chenzp@gzsums.edu.cn
EDUCATIONS:

  M.D., (1982): Suzhou Medical College, Suzhou, China.
  Ph.D.(1993):Suzhou Medical College, China
 1982 – 1987: Residency training for Neurosurgery, Suzhou Medical College, China.
 1993-1996: Postdoctoral training for Neurosurgery/Oncology, McGill University, Montreal, Canada.

PROFESSIONAL EXPERIENCES:

  1999-present: Professor & Chairman, Department of Neurosurgery/Neuro-Oncology, Cancer Center, Sun Yat-sen     University, Guangzhou, China.

  1996-1999:Research Associate, Department of Neurosurgery & Medical Oncology, Neuro-Oncology Section, SMBD-Jewish General Hospital, McGill University, Montreal, Canada.

  1997:Associate professor, Department of Neurosurgery, Brain Tumor Laboratory, Second Affiliated Hospital, Suzhou Medical College, China.

   1988-1993:Staff Neurosurgeon, First Affiliated Hospital, Suzhou Medical College, Suzhou, China.

MAJOR FIELD:

Clinical practice (Neurosurgery/Neuro-oncology):

    After successfully completed the Neurosurgical residency training and satisfied the Chinese National Standard of Neurosurgeon, I had been a full staff neurosurgeon at the First Affiliated Hospital of Suzhou Medical College, practicing on general neurosurgery. With skillful microneurosurgery technique, I highly experienced on dealing with brain and spinal tumor, head injury, and cerebral vascular diseases etc. I have been also trained with Dr.Gérard Mohr (McGill University) for cerebello-pontine angle tumor surgery, specifically for hearing preservation during acoustic neuroma surgery, and with Dr. Lawrence Panasci (McGill University) for medical neuro-oncology. Since later 1999, I have started Neurosurgery/Neuro-Oncology service at Cancer Center, Sun Yat-sen University, Guangzhou, China, focused on dealing with primary and metastatic tumors of central nervous system.

Molecular Neuro-Oncology:

    The main project is the study of genetic alterations leading to resistance of human brain tumors to chemotherapy. We have, for the first time, found and confirmed that ERCC2, one of the important components in nucleotide excision repair (NER) system related to alkylating agent drug resistance in human tumor cell lines. We also verified that MGMT contributed to chloroethylnitrosourea resistance in human tumor cell lines and in glioma patients. I have been also working on the project of developing a new anticancer analogue, SarCNU, which has been approved with enhanced antitumor activity against human gliomas in animal models, and currently has been in clinical trial phase I-II. Our investigation have suggested that the superior antitumor efficacy of SarCNU may related to the exhibit of extraneuronal monoamine transporter(EMT) on the tumor cells. We are currently also working on the projects of “Multidisciplinary therapy for glioma according its molecular aspect”, and “Molecular marker for early diagnosis of brain metastasis”. Presently, five research workers including post-doctor fellows, graduate students and technicians are working in the Neuro-oncology research group.

PRIZES & HONORS:

  1. The Second Prize of Expertise of Outcome of Scientific Research, Jiangsu Provincial Government, P.R. China. 2001(at 4th place)
  2. Francis McNaughton Memorial Prize. Canadian Neurological Society. 1998
  3. WHO Third Prize for Chinese Young Professional in Mental Health & Neuroscience. 1993
  4. Third Prize of Ministerial Expertise of Outcome of Scientific Research, P.R. China. 1992, 1998.

MEMBERSHIPS:

  1. Member of Chinese Neurosurgery Association (1992)
  2. Member of the Society for Experimental Biology and Medicine, U.S.A. (1995)
  3. Associate member of American Association for Cancer Research (1996)
  4. Associate member of American Society for Stereotactic and Functional Neurosurgery, and International Society for Stereotactic and Functional Neurosurgery (1996)
  5. International member of the Congress of Neurological Surgeon (1998)
  6. Associate member of Canadian Congress of Neurological Sciences (1998)
  7. Council Member of Guangzhou Anticancer Association(2001)
  8. Member of Asia Neurological Surgeon Conference (2002)

SOCIAL ACTIVITIES:

  1. President of Guangzhou Neuro-oncology Society
  2. Editorial member of “Chinese Journal of Cancer”
  3. Editorial member of “Chinese Journal of Minimally Invasive Neurosurgery”
  4. Editorial member of “Nervous Diseases and Mental Hygiene”(in Chinese)
  5. Editor-in-chief, “Neuro-Oncology Newsletter”(in Chinese)

SELECTED PUBLICATIONS:

  1. Chen Z-P, Malapetsa A, Marcantonio D, Mohr G, Brien S and Panasci LC. Correlation of chloroethylnitrosourea resistance with ERCC-2 expression in human tumor cell lines as determined by quantitative competitive polymerase chain reaction. Cancer Research. 1996;56: 2475-2478.
  2. Chen Z-P and Mohr G. Microencapsulation for cell implants into central nervous system: the importance of alginate viscosity and related factors. Stereotactic and Functional Neurosurgery. 1996;66:141-146.
  3. Chen Z-P and Mohr G. Pituitary cell transplantation. in Yearbook of cell and tissue transplantation (1996/1997), R.P Lanza and W.L. Chick (eds), Chapter 18, p,185-190. Kluwer Academic Publishers.
  4. Chen Z-P, Malapetsa A, Brien S, Mohr G, and Panasci LC. Quantitation of ERCC-2 expression by reverse-transcription polymerase chain reaction comparison to Northern blot analysis. Analytical Biochemistry 1997;244:50-54.
  5. Mohr G, Chen Z-P, Schweitzer M. Acromegaly with normal basal growth hormone levels. Can. J. Neurol. Sci. 1997;24:250-253.
  6. Chen Z-P, Malapetsa A, McQuillan A, Marcantonia D, Bello V, Mohr G, Remack J, Brent TP and Panasci LC. Evidence for nucleotide excision repair as a modifying factor of MGMT mediated innate chloroethylnitrosourea resistance in human tumor cell lines. Molecular Pharmacology 1997;52:815-820.
  7. Chen Z-P, McQuillan A, Mohr G and Panasci LC. ERCC2 gene expression and chloroethylnitrosourea resistance in human glioma cell lines. Neurosurgery 1998;42:1112-1119.
  8. Chen Z-P, Yarosh D, Garcia Y, Tampieri D, Langleben A, Mohr G, Malapetsa A, and Panasci LC. Relationship Between O6-methylguanine-DNA Methyltransferase Levels and Clinical Response Induced by Chloroethylnitrosourea Therapy in Glioma Patients. Can. J. Neurol. Sci. 1999; 26:104-109.
  9. Chen Z-P, Wang G, Huang Q,Sun Z-F,Zhou L-Y, Wang A-D, Panasci LC. Effectiveness of SarCNU in comparison to BCNU against human glioma xenografts. J Neuro-Oncology 1999; 44:7-17.
  10. Chen Z-P, Remack J, Brent TP, Mohr G and Panasci LC. Extraneuronal Monoamine Transporter Expression vis-à-vis SauCNU Cytotoxicity in Human Tumor Cell Lines. Clin Cancer Res 1999;5:4186-4190.
  11. Chen Z-P, Pan J, Huang Q,Sun Z-F, Zhou L-Y, Wang A-D, Panasci LC. Antitumor effect of SarCNU in a MGMT positive human glioma xenograft model. Chinese Journal of Cancer Research, 2000；12：1-4.
  12. Chen Z-P, Pan J, Huang Q, Sun Z-F, Zhou L-Y, Wang A-D. Antitumor efficacy of SarCNU in a Human Glioma Xenograft Model expressing both MGMT and Extraneuronal Monoamine Transporter. J Neuro-Oncology 2001;51：19-24.
  13. Chen Z-P, Carter CA, Alley MC, Mohr G, Panasci LC. Both Extraneuronal Monoamine Transporter and O6-methylguanine-DNA Methyltransferase Expression Influence the Antitumor Efficacy of SarCNU in Human Tumor Xenografts. J Pharmacol Exp Ther 2001,296(3):712-715.
  14. Wang Z-M, Chen Z-P, Xu Z-Y, Christodoulopoulos G, Bello V, Mohr G, Aloyz R, Panasci LC. In Vitro Evidence for Homologous Recombinational Repair in Resistance to Melphalan. J Natl Cancer Inst 2001;93:1473 –1478.
    15.
 
Cancer Center, Sun Yat-Sen University
ADD: 651 Dongfeng Road, East, Guangzhou, P. R. China TEL: (8620) 87343088  FAX: (8620)87343392