曾木圣:

          博士、研究员、博士生导师（生物化学与分子生物学）
　　入选2006年教育部新世纪优秀人才计划
学科：肿瘤学
专业特长: 恶性肿瘤发病机制、早期诊断和预后研究
研究方向：1. EB病毒致癌机制
　　　　　2. 鼻咽癌转移的分子机制
　　　　　3. 恶性肿瘤分子标志和早期诊断
联系电话：020-87343191;（Fax）：020-87343392，　Email: zengmsh@mail.sysu.edu.cn
通讯地址：广州市东风东路651号　中山大学肿瘤防治中心实验研究部　邮编 510060

【学术兼职】
1. 中国抗癌协会肿瘤标志专业委员会委员
2. 广东省预防医学会病毒学专业委员会委员
3. 《癌症》杂志常务篇委

【个人简介】
　　中山大学肿瘤防治中心研究员，博士生导师。1998年获得博士学位。

　　1999-2003年先后在美国田纳西州立大学生物系（Tennessee State University）、美国波士顿塔夫茨大学-纽英伦医学中心(Tufts University-New England Medical Center)肿瘤生物学实验室从事维甲酸在细胞发育及分化中作用的研究以及乳腺癌发病机理、诊断及预后指标的研究。

　　作为课题主持人获得国家自然科学基金5项、卫生部基金项目、广东省自然科学基金、教育部留学回国人员基金、CMB基金及“985 II” 重点学科建设经费各1项，并参与国家高新技术研究发展规划（863计划）及973分题等科研课题。发表论文30余篇，包括国际著名杂志Molecular and Cellular Biology，Int J Cancer，J Biol Chem，Cancer Research，Clinical Cancer Research，Journal of Virology及Cancer Letters，其中后5篇论著皆为2003年回国后在国内完成并发表。

　　回国后组建实验肿瘤学和肿瘤分子标志研究组，建立了成人正常鼻咽上皮细胞体外培养和单一原癌基因早期转化的首个体外模型(Cancer Research, 2006)，为克服常用培养方法的局限性，建立了能反映体内癌变动态过程的体外三维培养模型。此外，首次报道鼻咽癌患者来源的EB病毒全序列分析（世界上第二株EB病毒的序列分析），并发现鼻咽癌相关的EB病毒变异点。这些研究为最终阐明鼻咽癌发病机制奠定了良好的基础。

　　对于鼻咽癌诊断试剂的敏感性和特异性不尽理想的情况下，努力探索新的诊断指标和方法，并获得国家自然科学基金重点项目资助。

【代表性论著】(*通信作者)
1. Liao WT, Song LB, Zhang HZ, Zhang X, Zhang L, Liu WL, Feng Y, Guo BH, Mai HQ, Cao SM, Li MZ, Qin HD, Zeng YX, Zeng MS*. CENP-H is a Novel Prognostic Marker for Nasopharyngeal Carcinoma Progression and Overall Patient Survival. Clin Cancer Res（IF 5.6）, 2007，13(2):508-14.
2. Song LB, Zeng MS*, Liao WT, Zhang L, Mo HY, Liu WL, Shao JY, Wu QL, Li MZ, Xia YF, Fu LW, Huang WL, Dimri G, Band V and Zeng YX. Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells. Cancer Research（IF 7.7），2006；66 (12)：6225
3. Song LB, Liao WT, Mai HQ, Zhang HZ, Zhang L, Li MZ, Hou JH, Fu LW, Huang WL, Zeng YX, Zeng MS*. The Clinical Significance of Twist Expression in Nasopharyngeal Carcinoma. Cancer Letters（IF 2.9）2006；242（2）：257
4. Zeng MS, Li DJ, Liu QL, et al. Genomic sequence analysis of an Epstein-Barr virus strain GD1 from a nasopharyngeal carcinoma patient. J Virol （IF 5.3） 2005, 79 (24):15323-15330
5. Zeng M, Zhang Y, Bhat I, Wazer D and Band V. The human kallikrein 10 promoter contains a functional retinoid acid response element. Biol Chem.（IF 3.2）2006, 387（6）：741
6. Jiang RC, Qin HD, Zeng MS (前三位为同等贡献), et al. A functional variant in the transcriptional regulatory region of gene LOC344967 co-segregates with disease phenotype in familial nasopharyngeal carcinoma. Cancer Res（IF 7.8）, 2006; 66(2)：693-700
7. Zeng M, Kumar A, Meng G, Gao Q, Dimri G, Wazer D, Band H and Band V. Human papilloma virus 16 E6 oncoprotein inhibits RXR-mediated transactivation by targeting human ADA3 coactivator. J Biol Chem（IF 6.3） 2002; 277(47): 45611-45618
8. Mai SJ, Ooka T, Li DJ, Zeng MS, Jiang RC, Yu XJ, Zhang RH, Chen SP, Zeng YX. Functional advantage of NPC-related V-val subtype of Epstein-Barr virus nuclear antigen 1 compared with prototype in epithelial cell line. Oncol Rep. 2007; 17(1):141-6.
9. Song LB, Zhang X, Zhang CQ, Zhang Y, Pan ZZ, Liao WT, Li MZ, Zeng MS*. Infection of Epstein-Barr virus in colorectal cancer in Chinese. Ai Zheng. 2006; 25(11):1356-60.
10. Zhang NH, Zhang XS, Li J, Zhang RH, Gao YF, Zeng MS. [Sequence analysis of the CTL epitopes in transmembrane region of latent membrane protein 2 of Epstein-Barr virus derived from nasopharyngeal carcinoma cells]. Ai Zheng. 2006; 25(5):566-9. Chinese.
11. Wang N, Wu QL, Fang Y, Mai HQ, Zeng MS, Shen GP, Hou JH, Zeng YX. Expression of chemokine receptor CXCR4 in nasopharyngeal carcinoma: pattern of expression and correlation with clinical outcome. J Transl Med. 2005 Jun 26;3:26.
12. Wang XH, Jia DZ, Liang YJ, Yan SL, Ding Y, Chen LM, Shi Z, Zeng MS, Liu GF, Fu LW. Lgf-YL-9 induces apoptosis in human epidermoid carcinoma KB cells and multidrug resistant KBv200 cells via reactive oxygen species-independent mitochondrial pathway. Cancer Lett. 2006 Oct 19; [Epub ahead of print]
13. Dai CL, Xiong HY, Tang LF, Zhang X, Liang YJ, Zeng MS, Chen LM, Wang XH, Fu LW. Tetrandrine achieved plasma concentrations capable of reversing MDR in vitro and had no apparent effect on doxorubicin pharmacokinetics in mice. Cancer Chemother Pharmacol. 2007 Feb 2 [Epub ahead of print]
14. Jiang JH, Wang N, Li A, Liao WT, Pan ZG, Mai SJ, Li DJ, Zeng MS, Wen JM, Zeng YX. Hypoxia can contribute to the induction of the Epstein-Barr virus (EBV) lytic cycle. J Clin Virol. 2006; 37(2):98-103.
15. Liu JH, Huang H, Huang X, Zeng MS, Li W. [Expression of key cell cycle markers in squamous cell carcinoma of the cervix positive in human papillomavirus: a comparative study between Chinese and Australian populations]. Zhonghua Yi Xue Za Zhi. 2006; 86(5):312-6. Chinese.
16. Liao WT, Wang HM, Li MZ, Song LB, Zhang L, Mai HQ, Xia YF, Zheng ML, Fu LW, Zeng YX, Zeng MS. [Establishment of three-dimensional culture models related to different stages of nasopharyngeal carcinogenesis]. Ai Zheng. 2005; 24(11):1317-21. Chinese.
17. Kumar A, Zhao Y, Meng G, Zeng M, Srinivasan S, Delmolino LM, Gao Q, Dimri G, Weber GF, Wazer DE, Band H and Band V. Human papillomavirus oncoprotein E6 inactivates the transcriptional coactivator human ADA3. Mol Cell Biol（IF 9.3） 2002; 22(16): 5801-12
18. Meng G, Zhao Y, Nag A, Zeng M, Dimri G, Gao Q, Wazer DE, Kumar R, Band H,Band V. Human ADA3 binds to estrogen receptor (ER) and functions as a coactivator for ER-mediated transactivation. J Biol Chem（IF6.3）. 2004 Dec 24;279(52):54230-40
19. Asson Batres MA, Zeng MS, McKanna J, and Savchenko V. Vitamin A Deficiency Leads to Increased Cell Proliferation in Olfactory Epithelium of Mature Rats. J Nurobiol 2003, 54(4): 539.
20. Guoxiang, Min HQ, Zeng MS, et al. Nm23-H1 expression in nasopharyngeal carcinoma: Correlation with clinical outcome. Int J Cancer（IF 4.3）, 1998; 79, 596
21. 廖文婷…曾木圣(通信作者)。鼻咽癌变不同时期的体外三维培养模型建立的实验研究。癌症，2005；24（11）1317

【主持在研项目】
1. 国家自然科学基金重点项目（30630068） 鼻咽癌早期诊断的基础研究 2007-2010年140万元
2. 国家自然科学基金（30570701），野生型和广东鼻咽癌变异型EB病毒对成人正常鼻咽上皮细胞转化能力的比较研究。2006－2008。28万
3. 国家自然科学基金（30470666），三维培养模型研究广东鼻咽癌变异型EB病毒基因细胞转化作用。2005－2007。20万
4. 2006教育部新世纪优秀人才配套经费，50万
5. 广东省自然科学基金（04009427），三维培养研究广东鼻咽癌变异型EB病毒基因的转化功能。 2005－2006。5万
6. “973”计划，恶性肿瘤的分子分型和临床转归的预测 2004-2009。6.0万
7. “985工程”二期国家重点实验室建设基金。野生型和广东鼻咽癌变异型EB病毒对成人正常鼻咽上皮细胞转化能力的比较研究。2005-2007。30万
8. 教育部留学回国人员基金， 三维培养模型研究广东鼻咽癌变异型EB病毒基因细胞转化作用。2005—2007 2.0万
9. CMB基金，NES1在前列腺癌及卵巢癌中的表达及其对肿瘤细胞迁移及转移的抑制作用 2004－2006 1.5万美元

【国际会议】
1. Zeng MS, Liu QL…Zeng YX. Full-length sequencing and analysis of a EBV genome from a Cantonese NPC patient. Presentation. 2005 East-West Symposium on NPC in Toronto, Cannada in June 2005
2. Zeng M, Kumar A, Meng G, Gao Q, Dimri G, Wazer D, Band H and Band V. Human papilloma virus 16 E6 oncoprotein inhibits RXR-mediated transactivation by targeting human ADA3 coactivator. Poster Session at 2003 AACR Annual Meeting in Washington DC, USA in July, 2003.
3. Zeng MS, Ahmad O, Ong DE, Asson-Batres MA. Expression of cellular retinoic acid binding protein in mature rat olfactory epithelium. Poster at 2000 FASEB SUMMER RESEARCH CONFERENCES ON RETINOIDS. Copper Mountain, Colorado. June 25-30, 2000
4. Asson-Batres MA, Zeng MS. Vitamin A in olfactory mucosa and its effect on gene expression in neurons in vivo. Poster at 2000 FASEB SUMMER RESEARCH CONFERENCES ON RETINOIDS. Copper Mountain, Colorado. June 25-30, 2000
5. Aderoju AO, Zeng M, Asson-Batres MA. Effect of vitamin A on the mRNA expression levels of olfactory maker protein. Poster at AChemS on April 29, 2000

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